
| Overall | Div 1 | |
| Wins | 518 | 239 |
| Draws | 210 | 110 |
| Losses | 434 | 189 |
| Pct. | 0.536 | 0.546 |
| D.C. United (DC) | S15 - S15 |
| Chicago Fire (CHI) | S15 - S15 |
| Neale Morrice (S3-3), Vacant (S4-4), Dave Dowson (S5-24), Simon Bijker (S15-15), Mark Boland (S15-15), Allan Sellers (S24-28), |
| M | DATE | SCORE | OPPONENT | COMPETITION | HEAD TO HEAD RESULTS | LAST MATCH | |||
| 1 | Oct 05 | D | 2 - 2 | Portland Timbers | Allan Sellers Cup | Columbus Crew lead series 33-9-28 | |||
| 2 | Oct 08 | W | 4 - 2 | Austin FC | Allan Sellers Cup | Columbus Crew lead series 3-1-2 | |||
| 3 | Oct 12 | L | 2 - 3 | @ | Carolina RailHawks | Allan Sellers Cup | Columbus Crew lead series 37-15-35 | ||
| 4 | Oct 15 | D | 0 - 0 | Carolina RailHawks | Allan Sellers Cup | Columbus Crew lead series 37-15-35 | |||
| 5 | Oct 19 | W | 3 - 1 | @ | Austin FC | Allan Sellers Cup | Columbus Crew lead series 3-1-2 | ||
| 6 | Oct 22 | L | 1 - 2 | @ | Portland Timbers | Allan Sellers Cup | Columbus Crew lead series 33-9-28 | ||
| 7 | Oct 26 | L | 0 - 2 | @ | Carolina RailHawks | Division 1 | Columbus Crew lead series 37-15-35 | ||
| 8 | Oct 29 | L | 1 - 2 | Los Angeles FC | Division 1 | Los Angeles FC lead series 1-0-0 | |||
| 9 | Nov 02 | W | 4 - 3 | @ | Kansas City Wizards | Division 1 | Columbus Crew lead series 31-18-30 | ||
| 10 | Nov 05 | L | 0 - 3 | @ | Austin FC | Division 1 | Columbus Crew lead series 3-1-2 | ||
| 11 | Nov 09 | W | 6 - 2 | D.C. United | Division 1 | Columbus Crew lead series 19-12-11 | |||
| 13 | Nov 16 | D | 1 - 1 | @ | Portland Timbers | Division 1 | Columbus Crew lead series 33-9-28 | ||
| 15 | Nov 23 | W | 2 - 1 | @ | Atlanta United | Division 1 | Atlanta United lead series 21-11-18 | ||
| 17 | Nov 30 | W | 3 - 0 | (n) | Carolina RailHawks | Division 1 | Columbus Crew lead series 37-15-35 | ||
| 18 | Dec 03 | (n) | Los Angeles FC | Division 1 | Los Angeles FC lead series 1-0-0 | LAF 2-1 (Sea-36) | |||
| 19 | Dec 07 | (n) | Kansas City Wizards | Division 1 | Columbus Crew lead series 31-18-30 | CLB 4-3 (Sea-36) | |||
| 20 | Dec 10 | (n) | Austin FC | Division 1 | Columbus Crew lead series 3-1-2 | AUS 3-0 (Sea-36) | |||
| 21 | Dec 14 | (n) | D.C. United | Division 1 | Columbus Crew lead series 19-12-11 | CLB 6-2 (Sea-36) | |||
| 22 | Dec 17 | (n) | Portland Timbers | Division 1 | Columbus Crew lead series 33-9-28 | Draw 1-1 (Sea-36) | |||
| 23 | Dec 21 | (n) | Atlanta United | Division 1 | Atlanta United lead series 21-11-18 | CLB 2-1 (Sea-36) | |||
| 25 | Jan 04 | Carolina RailHawks | Division 1 | Columbus Crew lead series 37-15-35 | CLB 3-0 (Sea-36) | ||||
| 27 | Jan 11 | @ | Los Angeles FC | Division 1 | Los Angeles FC lead series 1-0-0 | LAF 2-1 (Sea-36) | |||
| 29 | Jan 18 | Kansas City Wizards | Division 1 | Columbus Crew lead series 31-18-30 | CLB 4-3 (Sea-36) | ||||
| 31 | Jan 25 | Austin FC | Division 1 | Columbus Crew lead series 3-1-2 | AUS 3-0 (Sea-36) | ||||
| 33 | Feb 01 | @ | D.C. United | Division 1 | Columbus Crew lead series 19-12-11 | CLB 6-2 (Sea-36) | |||
| 35 | Feb 08 | Portland Timbers | Division 1 | Columbus Crew lead series 33-9-28 | Draw 1-1 (Sea-36) | ||||
| 37 | Feb 15 | Atlanta United | Division 1 | Atlanta United lead series 21-11-18 | CLB 2-1 (Sea-36) | ||||