
| Overall | Div 1 | |
| Wins | 546 | 246 |
| Draws | 220 | 113 |
| Losses | 456 | 197 |
| Pct. | 0.537 | 0.544 |
| D.C. United (DC) | S15 - S15 |
| Chicago Fire (CHI) | S15 - S15 |
| Neale Morrice (S3-3), Vacant (S4-4), Dave Dowson (S5-24), Simon Bijker (S15-15), Mark Boland (S15-15), Allan Sellers (S24-28), |
| M | DATE | SCORE | OPPONENT | COMPETITION | HEAD TO HEAD RESULTS | LAST MATCH | |||
| 1 | Sep 20 | W | 3 - 1 | Kansas City Wizards | Allan Sellers Cup | Columbus Crew lead series 34-20-32 | |||
| 2 | Sep 23 | L | 0 - 2 | @ | Austin FC | Allan Sellers Cup | Columbus Crew lead series 6-2-4 | ||
| 3 | Sep 27 | W | 4 - 1 | Colorado Rapids | Allan Sellers Cup | Columbus Crew lead series 28-5-19 | |||
| 4 | Sep 30 | L | 0 - 2 | @ | Colorado Rapids | Allan Sellers Cup | Columbus Crew lead series 28-5-19 | ||
| 5 | Oct 04 | W | 2 - 1 | Austin FC | Allan Sellers Cup | Columbus Crew lead series 6-2-4 | |||
| 6 | Oct 07 | L | 0 - 2 | @ | Kansas City Wizards | Allan Sellers Cup | Columbus Crew lead series 34-20-32 | ||
| 7 | Oct 11 | L | 2 - 3 | Houston Dynamo | Division 1 | Columbus Crew lead series 38-12-30 | |||
| 8 | Oct 14 | W | 3 - 0 | @ | Austin FC | Division 1 | Columbus Crew lead series 6-2-4 | ||
| 9 | Oct 18 | W | 2 - 1 | @ | Atlanta United | Division 1 | Columbus Crew lead series 24-13-22 | ||
| 10 | Oct 21 | D | 2 - 2 | Portland Timbers | Division 1 | Columbus Crew lead series 33-10-30 | |||
| 11 | Oct 25 | W | 6 - 2 | @ | Charleston Battery | Division 1 | Columbus Crew lead series 22-8-7 | ||
| 12 | Oct 28 | L | 0 - 2 | (n) | Inter Miami | Allan Sellers Cup | Columbus Crew lead series 8-3-5 | ||
| 13 | Nov 01 | Carolina RailHawks | Division 1 | Columbus Crew lead series 38-15-37 | CAR 2-0 (Sea-37) | ||||
| 15 | Nov 08 | Los Angeles FC | Division 1 | Los Angeles FC lead series 3-0-0 | LAF 2-0 (Sea-36) | ||||
| 17 | Nov 15 | (n) | Houston Dynamo | Division 1 | Columbus Crew lead series 38-12-30 | HOU 3-2 (Sea-38) | |||
| 18 | Nov 18 | (n) | Austin FC | Division 1 | Columbus Crew lead series 6-2-4 | CLB 3-0 (Sea-38) | |||
| 19 | Nov 22 | (n) | Atlanta United | Division 1 | Columbus Crew lead series 24-13-22 | CLB 2-1 (Sea-38) | |||
| 20 | Nov 25 | (n) | Portland Timbers | Division 1 | Columbus Crew lead series 33-10-30 | Draw 2-2 (Sea-38) | |||
| 21 | Nov 29 | (n) | Charleston Battery | Division 1 | Columbus Crew lead series 22-8-7 | CLB 6-2 (Sea-38) | |||
| 22 | Dec 02 | (n) | Carolina RailHawks | Division 1 | Columbus Crew lead series 38-15-37 | CAR 2-0 (Sea-37) | |||
| 23 | Dec 06 | (n) | Los Angeles FC | Division 1 | Los Angeles FC lead series 3-0-0 | LAF 2-0 (Sea-36) | |||
| 25 | Dec 13 | @ | Houston Dynamo | Division 1 | Columbus Crew lead series 38-12-30 | HOU 3-2 (Sea-38) | |||
| 27 | Dec 20 | Austin FC | Division 1 | Columbus Crew lead series 6-2-4 | CLB 3-0 (Sea-38) | ||||
| 29 | Jan 03 | Atlanta United | Division 1 | Columbus Crew lead series 24-13-22 | CLB 2-1 (Sea-38) | ||||
| 31 | Jan 10 | @ | Portland Timbers | Division 1 | Columbus Crew lead series 33-10-30 | Draw 2-2 (Sea-38) | |||
| 33 | Jan 17 | Charleston Battery | Division 1 | Columbus Crew lead series 22-8-7 | CLB 6-2 (Sea-38) | ||||
| 35 | Jan 24 | @ | Carolina RailHawks | Division 1 | Columbus Crew lead series 38-15-37 | CAR 2-0 (Sea-37) | |||
| 37 | Jan 31 | @ | Los Angeles FC | Division 1 | Los Angeles FC lead series 3-0-0 | LAF 2-0 (Sea-36) | |||