| Division 1 |  Atlanta United | 3 |  Columbus Crew | 6 | | Neutral Venue | | |
| Division 1 |  Austin FC | 2 |  Kansas City Wizards | 2 | | Neutral Venue | | |
| Division 1 |  Carolina RailHawks | 3 |  Portland Timbers | 0 | | Neutral Venue | | |
| Division 1 |  D.C. United | 0 |  Los Angeles FC | 4 | | Neutral Venue | | |
| Division 2 |  Charleston Battery | 2 |  Houston Dynamo | 1 | | Neutral Venue | | |
| Division 2 |  Chivas USA | 1 |  Seattle Sounders | 1 | | Neutral Venue | | |
| | Division 2 |  Colorado Rapids | 4 |  Vancouver Whitecaps | 3 | | Neutral Venue | | |
| Division 2 |  Inter Miami | 3 |  San Jose Earthquakes | 2 | | Neutral Venue | | |
| Division 3 |  Carolina Dynamo | 2 |  Daniel Island S.A. | 2 | | Neutral Venue | | |
| Division 3 |  Colorado Ice White | 4 |  Mount Tabor Portland | 0 | | Neutral Venue | | |
| Division 3 |  De Anza Force S.C. | 5 |  Savannah Celtic FC | 0 | | Neutral Venue | | |
| | Division 3 |  Fort Lauderdale FC | 3 |  Columbus Rebels | 0 | | Neutral Venue | | |
| Division 4 |  Carson City Kickers | 1 |  Laredo Heat | 1 | | Neutral Venue | | |
| Division 4 |  D.C. Colts | 0 |  Orange County SC | 0 | | Neutral Venue | | |
| Division 4 |  KC Athletics | 3 |  Vancouver FC | 2 | | Neutral Venue | | |
| Division 4 |  North Sound Seawolves | 1 |  San Antonio FC | 2 | | Neutral Venue | | |
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